Sometimes a datastore get's removed without being disabled and unmounted carefully from your vSphere environment.
Especially if you have Storage IO Control enabled be sure to disable it, otherwise there are issues which are not easy to solve.
However in my latest case I found an easy solution:
Open a command prompt at an ESXi host or connect via secure shell (SSH) and issue the following command:
/etc/init.d/storageRM stop
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